Drug addiction, or substance use disorder (SUD), is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behaviour persist despite serious negative consequences.Drug abuse represents a problem that deserves great attention from a social point of view, and focuses on the importance of genetic studies to help in understandin

Introduction With almost 50% of cases preventable and the Australian National Bowel Cancer Screening Program in place, colorectal cancer (CRC) is a prime candidate for investment to reduce the cancer burden.The challenge is determining effective ways to reduce morbidity and mortality and their implementation through policy and practice.Pathways-Bow

The efficacy of 4 g 5-aminosalicylic acid (5-ASA, mesalamine) enemas was assessed in 666 patients with distal ulcerative colitis.Patients were enrolled in an open-label compassionate use program.One 4 g 5-ASA enema was administered each night for a period of four weeks and the disease activity index was assessed at baseline and on days 14 and 28.On

Designing nonlinear optimal controllers such as Minimum Variance Controller (MVC) has many difficulties.Main difficulties are 1) in order to design controller; the explicit relations between outputs and inputs must be executable.This relation is defined implicitly in the nonlinear models; 2) learning controller is high dimensional-multimodal optimi